Yeast Genetic Engineering
Yeastern’s genetic engineering system with food-grade baker’s yeast (Saccharomyces cerevisiae) mutants (patent pending) enables secretion or accumulation of high-quality heterologous proteins at either analytical or industrial scales. It is designed to lessen the risk and cost of pharmaceutical and biotechnology companies in high-quality protein production. Currently, we have completed the design and production of more than 20 proteins (peptide hormones, transmembrane proteins, industrial enzymes, nucleic acid binding proteins, drug proteins, viral antigens), and most have shown low glycosylation and high production. For our own, we have successfully produced herbal immunomodulatory proteins and algal SOD using this technology.
Yarrowia lipolytica is classified as GRAS (Generally Regarded As Safe) by the US FDA (Food and Drug Administration). Y. lipolytica, like E. coli and S.cerevisiae, can be manipulated easily and produces proteins with less hyperglycosylation. Y. lipolytica genetic engineering system is based on our YLEX Expression Kit, by which high level of heterologous proteins can be expressed intracellularly or be secreted from cells into the medium depending on customers’ desires.